Preface, XVII
Contributors, XIX
PART I PHYSIOLOGY
Section 1. Historical and Comparative Perspectives, 1Chapter 1. A History of the Science of Pigmentation, 3
Sidney N. Klaus
Chapter 2. Comparative Anatomy and Physiology of Pigment Cells in Nonmammalian Tissues, 9
Joseph T. Bagnara Section 2. The Morphology, Distribution, and Biology of the Pigment Cell, 41
Chapter 3. General Biology of Mammalian Pigmentation, 43
Walter C. Quevedo, Jr., and Thomas J. Holstein
Chapter 4. Extracutaneous Melanocytes, 59
Raymond E. Boissy
Chapter 5. Regulation of Melanoblast Migration and Differentiation, 75
Mark V. Reedy, David M. Parichy, Carol A. Erickson, Kenneth A. Mason, and Sally K. Frost-Mason
Chapter 6. The Biogenesis of Melanosomes, 97
Seth J. Orlow
Chapter 7. Melanosomal Translocation and Transfer, 107
Kowichi Jimbow and Sadao Sugiyama
Chapter 8. Regulation of Human Pigmentation by Ultraviolet Light and by Endocrine, Paracrine, and Autocrine Hormones, 115
Zalfa Abdel-Malek
Chapter 9. Melanocyte Interactions in the Skin, 123
David A. Norris, Joseph G. Morelli, and Mayumi Fujita
Chapter 10. Growth-Factor Receptors and Signal Transduction Regulating the Proliferation and Differentiation of Melanocytes, 135
Gisela Moellmann and Ruth Halaban
Chapter 11. Aging, Replicative Senescence, and the Differentiated Function of the Melanocyte, 151
Estela E. Medrano
Chapter 12. Advances in Long-Term Maintenance of Normal Human Melanocytes in Culture, 159
Zalfa Abdel-Malek
Chapter 13. Advances in Immortalization of Cultured Melanocytes and Melanoblasts, 165
Dorothy C. Bennett and Elena V. Sviderskaya
Chapter 14. Advances in Melanogenic Assays and Subcellular Fractionation, 175
Huiquan Zhao
Chapter 15. Regulation of Melanogenesis by the MSH Receptor, 183
Dongsi Lu, Wenbiao Chen, and Roger D. Cone Section 3. The Molecular Biology of the Pigment Cell, 199
Chapter 16. Molecular Approaches to the study of the Pigment Cell, 201
William S. Oeting and Richard A. King
Chapter 17. Piebaldism, Waardenburg Syndrome, and Related Genetic Disorders-Molecular and Genetic Aspects, 207
Richard A. Spritz
Chapter 18. Anatomy of Pigment Cell Genes Acting at the Cellular Level, 217
Murray H. Brilliant and Gregory S. Barsh
Chapter 19. Anatomy of Pigment Cell Genes Acting at the Subcellular Level, 231
William S. Oetting
Chapter 20. Genetic Regulation of the Pigment Cell, 251
Shigeki Shibahara, Ken-Ichi Yasumoto, and Kazuhiro Takahashi
Chapter 21. Advances in Transgenic Animal Models, 275
Friedrich Beerman
Chapter 22. Advances in In Vitro Gene Expression, 283
Vijayasaradhi Setaluri
Chapter 23. Advances in Gene Mapping, 291
William J. Pavan Section 4. Chemistry and Physics of Melanin and Enzymology of Melanin Synthesis, 305
Chapter 24. The Chemistry of Melanins and Related Metabolites, 307
Giuseppe Prota, Marco D'Ischia, and Alessandra Napolitano
Chapter 25. The Physical Properties of Melanins, 333
Tadeusz Sarna and Harold A. Swartz
Chapter 26. The Photobiology of the Tanning Response, 359
Barbara A. Gilchrest, Hee-Young Park, Mark S. Eller, and Mina Yaar
Chapter 27. The Toxicology and Pharmacology of Melanins, 373
Bengt S. Larsson
Chapter 28. The Enzymology of Melanogenesis, 391
John M. Pawelek and Ashok K. Chakraborty
Chapter 29. Mechanisms of Inhibition of Melanin Pigmentation, 401
Patrick A. Riley
Chapter 30. Regulation of Melanin Formation, 423
Vincent J. Hearing
Chapter 31. Advances in Chemical Analysis of Melanins, 439
Shosuke Ito
Chapter 32. Advances in Physical Analysis of Melanins, 451
Mark J. Nilges
Chapter 33. Advances in Enzymatic Anbalysis of Melanogenesis, 461
Francisco Solano and Jose C. Garcia-Borron PART II PATHOPHYSIOLOGY Section 5. An Overview of Human Skin Color and Its Disorders, 473
Chapter 34. The Normal Color of Human Skin, 475 James J. Nordlund and Jean-Paul Ortonne
Chapter 35. Mechanisms That Cause Abnormal Skin Color, 489 Jean-Paul Ortonne and James J. Nordlund Section 6. Disorders of Hypopigmentation and Depigmentation, 503
Chapter 36. Genetic Hypomelanoses: Disorders Characterized by Congenital Depigmentation, 505
Piebaldism, Waardenburg Syndrome, and Related Genetic Disorders, 505 Richard A. Spritz
Piebaldism with Deafness (Woolf's Syndrome), 510 Jean-Paul Ortonne
X-Linked Hypomelanosis-Deafness Syndrome (Ziprkowski-Margolis Syndrome), 511 Jean-Paul Ortonne
Chapter 37. Genetic Hypomelanoses: Disorders Characterized by Acquired Depigmentation, 513 Rozycki Syndrome (221350), 513 Jean L. Bolognia
Vitiligo Vulgaris, 513 J. Nordlund and Jean-Paul Ortonne
Chapter 38. Genetic Hypomelanoses: Disorders Characterized by Generalized Hypomelanoses, 553
Albinism, 553 Richard A. King
Ataxia-Telangiectasia, 575 Anne-Sophie Gadenne
Hallerman-Streiff Syndrome, 576 James J. Nordlund
Histidinemia, 577 Marnie D. Marx
Homocystinuria, 578 Allan D. Mineroff
Hypomelanoses and Immunodeficiencies, 579 Noreen A. Lemak and Madeleine Duvic
Kappa-Chain Deficiency, 584 Jean-Paul Ortonne
Menkes'Kinky Hair Syndrome, 584 Tanusin Ploysangam
Oculocerebral Syndrome with Hypopigmentation, 586 Jean L. Bolognia
Phenylketonuria, 590 Allan D. Mineroff
Tietz Syndrome, 591 Jean-Paul Ortonne
Chapter 39. Genetic Hypomelanoses: Disorders Characterized by Localized Hypomelanosis, 593
Focal Dermal Hypoplasia, 593 James J. Nordlund
Hypomelanosis of Ito and Mosaicism, 594 Wolfgang Küster, Torsten Ehrig, and Rudolf Happle
Hypomelanosis with Punctate Keratosis of the Palms and Soles, 601 Jean L. Bolognia
Darier-White Disease (Keratosis Follicularis; 124200), 602 Jean L. Bolognia
Nevus Depigmentosus, 604 Stella D. Calobrisi, 604
Tuberous Sclerosis Complex, 606 Pranav B. Sheth
Chapter 40. Genetic Hypomelanoses: Disorders Characterized by Hypopigmentaion of the Hair, 611
Bird-Headed Dwarfism (Seckel's Syndrome), 611 Stan P. Hill
Down's Syndrome, 612 Rosemary Geary
Fish Syndrome, 613 Stan P. Hill
Hereditary Premature Canities, 613 James J. Nordlund
Mandibulofacial Dysostosis (Treacher Collins Syndrome), 614 Rosemary Geary
Myotonic Dystrophy, 614 Peggy Tong
PHC Syndrome (Book Syndrome), 615 Stan P. Hill
Pierre Robin Syndrome, 615 James J. Nordlund
Prolidase Deficiency, 615 Pranav B. Sheth
Chapter 41. Metabolic, Nutritional, and Endocrine Disorders, 617
Kwashiorkor, 617 Peter S. Friedmann
Hypopituitarism, Hypogonadism, and Cushing's Syndrome, 620 Peter S. Friedmann
Chapter 42. Chemical, Pharmacologic and Physical Agents Causing Hypomelanoses, 621
Chemical and Pharmacologic Agents, 621 Kowichi Jimbow and Mihoko Jimbow
Physical Agents, 627 Jean-Philippe Lacour
Chapter 43. Infectious Hypomelanoses, 629 Jean-Philippe Lacour
Chapter 44. Inflammatory Hypomelanoses, 641 Jean-Philippe Lacour
Chapter 45. Neoplastic Hypomelanoses, 647 Jean-Claude Bystryn and Zhong Xie
Chapter 46. Miscellaneous Hypomelanoses: Disorders Characterized by Depigmentation, 663
Alezzandrini's Syndrome, 663 Wiete Westerhof, Davide Njoo, and Henk E. Menke
Idiopathic Guttate Hypomelanosis (IGH), 665 Wiete Westerhof, David Njoo, and Henk E. Menke
Leukoderma Punctata (LP), 667 Wiete Westerhof, David Njoo, and Henk E. Menke
Lichen Sclerosus et Atrophicus, 669 Philippe Bahadoran
Vagabond's Leukomelanoderma, 670 Wiete Westerhof, David Njoo, and Henk E. Menke
Vogt-Koyanagi-Harada Syndrome (VKHS), 672 Wiete Westerhof, David Njoo, and Henk E. Menke
Westerhof Syndrome, 678 Wiete Westerhof, David Njoo, and Henk E. Menke
Chapter 47. Miscellaneous Hypomelanoses: Disorders Characterized by Hypopigmentation, 683
Disseminated Hypopigmented Keratoses, 683 Wiete Westerhof, David Njoo, and Henk E. Menke
Hypermelanocytic Punctata and Guttata Hypomelanosis (HPGH), 684 Wiete Westerhof, Davis Njoo, and Henk E. Menke
Progressive Macular Hypomelanosis of the Trunk, 686 Henk E. Menke, David Njoo, and Wiete Westerhof
Sarcoidosis, 688 Henk E. Menke, David Njoo, and Wiete Westehof
Chapter 48. Miscellaneous Hypomelanoses: Disorders Characterized by Extracutaneous Loss of Pigmentation, 693
Alopecia Areata, 693 Wiete Westerhof, David Njoo, and Henk E. Menke
Heterochromia Irides, 695 Wiete Westerhof, David Njoo, and Henk E. Menke
Senile Canities, 698 Wiete Westherhof, David Njoo, and Henk E. Menke
Sudden Whitening of Hair, 702 Wiete Westerhof, David Njoo, and Henk E. Menke
Chapter 49: Hypopigmentation Without Hypomelanosis, 707 Jean-Philippe Lacour Section 7. Disorders of Hyperpigmentation, 709
Chapter 50. Genetic Epidermal Syndromes: Disorders Characterized by Generalized Hyperpigmentation, 711
Adrenoleukodystrophy (ALD), 711 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Familial Progressive Hyperpigmentation, 713 Nancy Burton Esterly, Eulalia Baselga, Beth A. Drolet, Susan Bayliss Mallory, and Sharon A. Foley
Fanconi's Anemia, 715 Amy A. Vaughan, Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Gaucher's Syndrome, 716 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Chapter 51. Genetic Epidermal Syndromes: Disorders Characterized by Reticulated Hyperpigmentation, 719
Berlin's Syndrome, 719 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Cantu's Syndrome, 720 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Congenital Poikiloderma with Bullae (Kindler's Syndrome), 720 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Dermatopathia Pigmentosa Reticularis, 722 Nancy Burton Esterly, Eulalia Baselga, Beth A. Drolet, Kazunori Urabe, Juichiro Nakayama, and Yoshiaki Hori
Dyschromatosis Universalis Hereditaria, 724 Sungbin Im
Epidermolysis Bullosa with Mottled Pigmentation, 725 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Familial Mandibuloacral Dysplasia, 726 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Hereditary Acrokeratotic Poikiloderma, 728 Kazunori Urabe, Juichiro Nakayama, Yoshiaki Hori, Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Hereditary Sclerosing Poikiloderma, 730 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Mendes da Costa Syndrome, 731 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Naegeli-Franceschetti-Jadassohn Syndrome, 732 Rosemary Geary
Reticulated Acropigmentation of Dohi (Dyschromatosis Symmetrica Hereditaria), 733 Sungbin Im, Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Reticulated Acropigmentation of Kitamura, 735 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Rothmund-Thomson Syndrome, 736 Anne-Sophie J. Gadenne, Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Chapter 52. Genetic Epidermal Syndromes: Disorders Characterized by Café au Lait Macules, 741
Familial Multiple Café au Lait Spots, 741 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Neurofibromatosis, 741 Nancy Burton Esterly, Eulalia Baselga, Beth A. Drolet, and Alina G. Bridges
Neurofibromatosis 1 with Noonan's Syndrome, 747 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Polyostotic Fibrous Dysplasia (McCune-Albright Syndrome), 748 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Segmental Neurofibromatosis, 749 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Silver-Russell Syndrome, 751 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Watson's Syndrome, 753 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Cahpter 53. Genetic Epidermal Syndromes: Disorders Characterized by Lentigines, 755
Lentigo Simplex, 755 Mary K. Cullen
Lentigo Senilis et Actinicus, 760 Mary K. Cullen
Centrofacial Lentiginosis, 766 Mary K. Cullen
LEOPARD Syndrome, 770 Mary K. Cullen
The Myxoma Syndrome: NAME and LAMB, 778 Mary K. Cullen
Carney Complex, 781 Mary K. Cullen
Peutz-Jeghers Syndrome, 790 Nancy Burton Esterly, Eulaia Baselga, and Beth A. Drolet
Other Lentiginoses, 792 Mary K. Cullen
Chapter 54. Genetic Epidermal Syndromes: Disorders Characterized by Localized Hyperpigmentation, 799
Anonychia with Flexural Pigmentation, 799 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Incontinentia Pigmenti, 800 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Mosaicism and Chimerism, 803 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Periorbital Hyperpigmentation, 804 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Pigmentary Demarcation Lines, 805 Nancy Burton Esterly, Eulalia Baselga, Beth A. Drolet, and Anita P. Sheth
Reticulated Pigmented Anomaly of the Flexures (Dowling-Degos Syndrome), 807 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Chapter 55. Genetic Epidermal Syndromes: Disorders of Hyperpigmentation and Premature Aging, 809
Acrogeria, 809 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Metageria, 811 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Progeria, 811 Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Xeroderma Pigmentosum, 813 Anita P. Sheth, Nancy Burton Esterly, Eulalia Baselga, and Beth A. Drolet
Werner's Syndrome, 817 Nancy Burton Esterly, Eulalia Baselga, Beth A. Drolet, and Cindy L. Lamerson
Chapter 56. Congenital Epidermal Hypermelanoses, 821
Dyskeratosis Congenita, 821 Susan Bayliss Mallory and Sharon A. Foley
Ectodermal Dysplasias, 823 Susan Bayliss Mallory and Sharon A. Foley
Transient Neonatal Pustular Melanosis, 826 Susan Bayliss Mallory and Sharon A. Foley
Universal Acquired Melanosis, 827 Susan Bayliss Mallory and Sharon A. Foley
Chapter 57. Acquired Epidermal Hypermelanoses, 829
Acanthosis Nigricans, 830 Norman Levine, Charles S. Fulk, and Randi Rubenzik
Acromelanosis Progressiva, 835 Norman Levine, Charles S. Fulk, and Randi Rubenzik
Atrophoderma of Pasini and Pierini, 836 James J. Nordlund, Norman Levine, Charles S. Fulk, and Randi Rubenzik
Becker's Nevus, 838 Norman Levine, Charles S. Fulk, and Randi Rubenzik
Café au Lait Spots, 839 Norman Levine, Charles S. Fulk, and Randi Rubenzik
Carcinoid Syndrome, 841 Norman Levine, Charles S. Fulk, and Randi Rubenzik
Confluent and Reticulated Papillomatosis, 843 Norman Levine, Charles S. Fulk, and Randi Rubenzik
Cutaneous Amyloidosis, 845 Norman Levine, Charles S. Fulk, and Randi Rubenzik
Dermatosis Papulosa Nigra, 848 Norman Levine, Charles S. Fulk, and Randi Rubenzik
Ephelides (Freckles), 849 Norman Levine, Charles S. Fulk, and Randi Rubenzik
Erythema Ab Igne, 851 Norman Levine, Charles S. Fulk, and Randi Rubenzik
Erythema Dyschromicum Perstans, 852 Norman Levine, Charles S. Fulk, and Randi Rubenzik
Erythromelanosis Follicularis Faciei et Colli, 854 Norman Levine, Charles S. Fulk, and Randi Rubenzik
Erythrose Peribuccale Pigmentaire of Brocq, 856 Norman Levine, Charles S. Fulk, and Randi Rubenzik
Extrapituitary Neuroendocrine Melanoderma, 857 Norman Levine, Charles S. Fulk, and Randi Rubenzik
Felty's Syndrome and Rheumatoid Arthritis, 858 Norman Levine, Charles S. Fulk, and Randi Rubenzik
Hyperpigmentation Associated with Human Immunodeficiency Virus (HIV) Infection, 859 Philippe Bahadoran
Hyperpigmentation Associated with Scleromyxedema and Gammopathy, 863 Kazunori Urabe, Juichiro Nakayama, and Yoshiaki Hori
Ichthyosis Nigricans Keratoses, and Epidermal Hyperplasia, 863 James J. Nordlund
Intestinal Pigmented Anomaly of the Flexures (Cronkhite-Canada Syndrome), 865 James J. Nordlund
Melanoacanthoma, 866 Norman Levine, Charles S. Fulk, and Randi Rubenzik
Morphea and Scleroderma, 868 James J. Nordlund
Pellagra, 870 Alina G. Bridges
Phytophotodermatitis, 872 Norman Levine, Charles S. Fulk, and Randi Rubenzik
Pigmentary Changes in Addison's Disease with Adrenal Insufficiency, 875 Cindy L. Lamerson and James J. Nordlund
Pigmentary Changes Associated with Cutaneous Lymphomas, 878 Debra L. Breneman
Poikiloderma of Civatte, 883 Sungbin Im
Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes: POEMS Syndrome, 884 James J. Nordlund
Porphyria Cutanea Tarda, 886 Stan P. Hill
Riehl's Melanosis, 889 Kazunori Urabe, Juichiro Nakayama, and Yoshiaki Hori
Urticaria Pigmentosum and Mastocytosis, 891 James J. Nordlund
Chapter 58. Acquired and Congenital Dermal Hypermelanoses, 895
Acquired Facial Blue Macules Resembling a Bilateral Nevus of Ota, 895 Kazunoki Urabe, Juichiro Nakayama, and Yoshiaki Hori
Carleton-Biggs Syndrome, 896 Kazunoki Urabe, Juichiro Nakayama, and Yoshiaki Hori
Linear Dermal Melanocytosis, 896 Kazunoki Urabe, Juichiro Nakayama, Yoshiaki Hori, Yoon-Kee Park, Seung Kyung Hann, and Sungbin Im
Nevus of Ito, 897 Kazunoki Urabe, Juichiro Nakayama, and Yoshiaki Hori
Nevus of Ota, 898 Kazunoki Urabe, Juichiro Nakayama, Yoshiaki Hori, Susan Bayliss Mallory, Sharon A. Foley, Yoon-Kee Park, Seung Kyung Hann, and Sungbin Im
Generalized Dermal Melanocytosis, 902 Yoon-Kee Park, Seung Kyung Hann, Sungbin Im, Kazunoki Urabe, Juichiro Nakayama, and Yoshiaki Hori
Phakomatosis Pigmentovascularis, 903 Yoon-Kee Park, Seung Kyung Hann, Sungbin Im, Kazunoki Urabe, Juichiro Nakayama, and Yoshiaki Hori
Sacral Spot of Infancy, 905 Yoon-Kee Park, Seung Kyung Hann, Sungbin Im, Kazunori Urabe, Juichiro Nakayama, and Yoshiaki Hori
Chapter 59. Mixed Epidermal and Dermal Hypermelanoses, 909
Melasma, 909 Kazunori Urabe, Juichiro Nakayama, and Yoshiaki Hori
Melanosis from Melanoma, 911 Kazunoki Urabe, Juichiro Nakayama, and Yoshiaki Hori
Chapter 60. Drug-Induced or -Related Pigmentation, 915 Daniel B. Dubin, Alice R. Barba, and Arthur J. Sober
Chapter 61. The Melanocyte System of the Nails and Its Disorders, 937 Antonella Tosti, Bianca Maria Piraccini, and Robert Baran
Chapter 62. Unusual Benign Neoplasms, 945
Melanotic Neuroectodermal Tumor of Infancy, 945 Jean L. Bolognia and Marya Alvarez-Franco
The Nevus Aversion Phenomenon, 951 James J. Nordlund
Pigmented Spindle Cell Nevi, 952 Jean L. Bolognia
Pilar Neurocristic Hamartoma, 956 Jean L. Bolognia
Speckled Lentiginous Nevus (Nevus Spilus), 958 Jean L. Bolognia Section 8. Treatment of Pigmentary Disorders, 967
Chapter 63. Topical Treatment of Pigmentary Disorders, 969 Rebat Halder and James J. Nordlund
Chapter 64. Phototherapy for Pigmentary Disorders, 977 Rebat Halder and James J. Nordlund
Chapter 65. Sunscreens and Cosmetics, 985 James J. Nordlund and Rebat Halder
Chapter 66. Surgical Treatment of Pigmentary Disorders, 987 Rebat Halder and James J. Nordlund
Chapter 67. Laser Treatment of Pigmentary Disorders, 995 Rebat Halder and James J. Nordlund
Giuseppe Prota
Universita Degli Studi di Napoli Federico II
Dipartimento di Chimica Organica e Biological, Italy
October 1992, 277 pp., isbn 0-12-565970-9
Audience: Cell biologists,biochemists,
research physicians and dermatologists,libraries,
and medical libraries.
MARKETING CODES : 2100 2500 5200
This book focuses on all aspects of melanin pigmentation, providing a concise, comprehensive picture of new knowledge gained at the frontiers of research. It draws heavily on the authors's 30-year activity in the field and his continuing work with specialists of widely diverse disciplines. The core of the book deals with the structure, physicochemical properties, and biosynthesis of the major classes of melanin pigments, including neuromelanins. Other discussions include the biology of the various types of pigment producing cells, the structure and mode of action of tyrosinase, and the chemistry of urinary melanogens and their biomedical applications as metabolic markers of melanocyte activity, especially for the follow-up of malignant melanoma. Finally, the book considers progress in the photobiology and photochemistry of melanins, with special emphasis on the controversial role of these pigments in skin photoprotection. This book is ideally suited as a basic guide for newcomers, and a handy source of specific information for practioners in academic, medical and industrial settings.
CONTENTS : An Introduction to Melanin Research. Melanin Producing Cells. Tyrosinase. Natural and Synthetic Melanins. Eumelanins. Neuromelanins. Pheomelanins and Trichochromes. Pigment Cell Metabolism. Enzymatic and Chemical Control. Genetic and Hormonal Regulation of Melanogenesis. Photobiology and Photochemistry of Melanogenesis. Chapter References. Subject Index. List of Abbreviations.
Academic Press
Harcourt Brace Jovanovich, Publishers Book Marketing Dept
179131250 Sixth Ave, San Diego, CA 92101-4311, U.S.A.
Malignant Melanoma
Medical and Surgical Management
F.J. Lejeune
P.K. Chaudhuri
T.K. Das Gupta
isbn 0-07-105421-9
1994, McGraw-Hill, inc.
Collected Papers from the Proceedings of the XV th IPCC
The Collected Papers selected fropm the Proceedings of the Kensington Town Hall, London,
September 26-30, 1993, are offered as a valuable limited edition. This is a unique
collector's item that will grace any research library. The volume is available now in an
attractive phaeomelanic softback cover at the eminently affordable price of £36.00
(Sterling) (US $55.00). This price includes postage.
Rush now to buy your copy while stocks last !
Send your order to :
International Pigment Cell Conference (Publications)
Department of Molecular Pathology
UCL Medical School
46 Cleveland Street
London W1P6DB, U.K.
Melanogenesis and the Malignant Melanoma: Biochemistry, Cell
Biology, Molecular Biology, Pathophysiology, Diagnosis and Treatment
Edited by: Y. Hori, V.J. Hearing, J. Nakayama.
ISBN 0-444-82209-7
The purpose of this symposium was to promote communication and to increase the level of
exchange of information on melanogenesis, pigmentary disorders and malignant melanoma. The
rapid progress in both the basic science and clinical medicine has necessitated a better
understanding of the biological significance of melanin and malignant melanoma in order to
be able to cure malignant melanoma. This book will be of help to the readers by
stimulating both further study and the promotion of more extensive understanding of
melanogenesis, pigmentary disorders and treatment of malignant melanoma. All the presented
papers in this symposium have been collected and published in this book.
Contents: Due to space limitations only a number of papers have been listed. Full contents list are available upon request.
Preface. Biochemistry and molecular biology of melanogenesis in benign and malignant tissues. Molecular genetics of normal and abnormal melanogenesis (W.S. Oetting et al.). Melanin-related metabolites: a new look at their functional role (G. Prota, G. Misuraca). Spectrophotometric and HPLC characterization of hair melanins (A. Ito, H. Ozeki, K. Wakamatsu). Autocrine and paracrine control of melanocytes (J.J. Nordlund).
Immunological approaches for malignant melanoma. Active specific immunotherapy of melanoma with anti-id mAb MK2-23: clinical and experimental investigations (Y. Moroi et al.). Restricted TCR repertoire in TIL of metastatic lung melanoma (M. Taniguchi et al.). Melanogenetic proteins as specific melanoma antigens (V.J. Hearing Jr.).
Biochemical analysis on the expression of specific proteins in melanoma. Serum 5-S-Cyteinyldopa in patients with metastatic melanoma (T. Horikoshi et al.). Detoxification processes in pigment-producing cells (S. Pavel, N.P.M. Smit). Glycolipids of melanoma (T. Tsuchida, S. Ikeda).
Diagnosis of malignant melanoma. Development of cell morphologic and molecular variables in melanoma prognosis (H.R. Byers, M.C. Mihm Jr.). A videomicroscopic approach to malignant melanoma (R Akasu et al.).
Treatment of malignant melanoma. New trends in the treatment of cutaneous melanoma (N. Cascinelli). Melanogenesis as a basis for specific targeting of malignant melanoma (B.S. Larsson).
Immunology of Human Melanoma
Tumor-Host Interaction and Immunotherapy
Edited by Michele MAIO ISBN 905199253 X
Biomedical and Health Research, Volume 12
IOS Press, 1996, Ohmsha
Amsterdam, Oxford, Tokyo, Washington, DC
ISSN: 0929-6743
Contents
Immunobiology of melanoma: an Overview, G Parmiani
Current Epidemiology of Malignant Melanoma, R.M. MacKie
Sections 1: Adhesion Molecules and Cytokines
Section 2: HLA Antigens and Accessory Molecules
Section 3: Tumor Antigens Recognition (In Vitro and In Vivo)
Section 4: Immunotherapy
Index
Melanocytic Tumors - A guide to diagnosis
Alistair J. Cochran
Christiane Bailly
Eberhard Paul
Fabrizio Remotti
with a contribution of Sunita Bhuta
Biopsy Interpretation Series, Lippincott - Raven Publishers, Philadelphia, New-York
ISBN: 0-397-51633-9
Contents:
1 Introduction and Basic Considerations
2 Common Nevi
3 Variants of Common Nevi
4 Blue Nevi and Related Lesions
5 Spitz and Related Nevi
6 Histology of Common Forms of Cutaneous Melanoma
7 Histology of Variants of Cutaneous Melanoma
8 Variants of Primary Cutaneous Melanoma That Simulate Other Melanocytic and
nonmelanocytic Lesions
9 Metastatic Melanoma
10 Characteristics that Relate to Prognosis
11 Techniques in the Evaluation of Melanocytic Lesions
12 The Diagnosis of Melanocytic Tumors
13 Algorithm for the Diagnosis of Melanocytic Tumors Located in the Epidermis
14 Algorithm for the Diagnosis of Compound Melanocytic Tumors
15 Algorithm for the Diagnosis of Melanocytic Tumors in the Dermis and/or Subcutaneous
Tissues
Index
